Anatomical Correlation of Phonological Dyslexia in Primary Progressive Aphasia
(PPA)
 
   Lead Investigator:    Simon Kang Seng Ting
   Institution      :    National Neuroscience Institute
   E-Mail           :    simon.ting.k.s@sgh.com.sg
   Proposal ID      :    663


   Publications:


1  Ting SK, Foo H, Chia PS, Hameed S, Ng KP, Ng A, Kandiah N
   Dyslexic Characteristics of Chinese-Speaking Semantic Variant of Primary Progressive Aphasia
   Journal Article  J Neuropsychiatry Clin Neurosci,30:31-37,2018,PMC5794526

   PUBLISHED





   Proposal Description:
   Background                                                                        Deep dyslexia, characterized by semantic errors during reading, is perhaps the    most extensively studied central dyslexias [1]. The failure to produce a          phonologically matched but semantically relevant response suggests impairment     of processes mediating the access of stimuli to the visual word form system       [2]. While current literature describes deep dyslexia mostly being observed in    the left hemisphere, especially in relation to large perisylvian lesions          extending to frontal lobe [1], hemispheric laterality functional correlation in   producing such phenomenon remains controversial [3]. To date, deep dyslexia       study in neurodegenerative model particularly PPA remains sparse we propose a     study to look into anatomical functional correlation of deep dyslexia from a      neurodegenerative model perspective. Hypothesis 1: Presence of deep dyslexia is   positively correlated to left temporal and negatively correlated to right         temporal lobe atrophy. Hypothesis 2: Deep dyslexia errors are positively          correlated to temporal lobe white matter volume.                                  Methods                                                                           Inclusion Criteria                                                                Patients from NACC database with clinical diagnosis of PPA (UDS form D1 item 13   code 1 and UDS-FTLD module form B9F item 1 code 1) will be included in the        study.                                                                            Data elements requested for all visits (only first visit):                        1. Demographics (Age onset, birth day/month, gender, education level, ethnic,     MMSE, CDR):                                                                       a. Form A1: 7, 8, 13, 14, 20, NACCNIHR                                            b. Form B4